Characterization of the metabolism of eupalinolide A and B by carboxylesterase and cytochrome P450 in human liver microsomes

• Main Authors: Yingzi Li (Author), Xiaoyan Liu (Author), Ludi Li (Author), Tao Zhang (Author), Yadong Gao (Author), Kewu Zeng (Author), Qi Wang (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Eupalinolide A (EA; Z-configuration) and eupalinolide B (EB; E-configuration) are bioactive cis-trans isomers isolated from Eupatorii Lindleyani Herba that exert anti-inflammatory and antitumor effects. Although one pharmacokinetic study found that the metabolic parameters of the isomers were differ...