Novel oral SPT inhibitor CH5169356 inhibits hepatic stellate cell activation and ameliorates hepatic fibrosis in mouse models of non‐alcoholic steatohepatitis (NASH)

• প্রধান লেখক: Natsuko Hada (লেখক), Asao Katsume (লেখক), Kawasaki Kenichi (লেখক), Chihiro Endo (লেখক), Naoshi Horiba (লেখক), Masayuki Sudoh (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2023-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Ceramide is a central molecule of sphingolipid metabolism and is involved in the development of non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH). It has already been reported that the inhibition of serine palmitoyltransferase (SPT), the rate‐limiting enzyme...