Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach

• Egile Nagusiak: Elisabetta Pancani (Egilea), Mario Menendez-Miranda (Egilea), Alexandra Pastor (Egilea), François Brisset (Egilea), Marie-Françoise (Egilea), Didier Desmaële (Egilea), Ruxandra Gref (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2018-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Nowadays, biodegradable polymers such as poly(lactic acid) (PLA), poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(ε-caprolactone) (PCL) remain the most common biomaterials to produce drug-loaded nanoparticles (NPs). Pipemidic acid (PIP) is a poorly soluble antibiotic with a strong tendency to crys...