Improved Malaria Therapy with Cationic Nanocapsules Demonstrated in <i>Plasmodium berghei</i>-Infected Rodents Using Whole Blood Surrogate Population PK/PD Modeling

• Hlavní autoři: Tamara Ramos Maciel (Autor), Ana Claudia Funguetto-Ribeiro (Autor), Laura Ben Olivo (Autor), Flávia Elizabete Guerra Teixeira (Autor), Camila de Oliveira Pacheco (Autor), Bibiana Verlindo de Araujo (Autor), Sandra Elisa Haas (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2024-10-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

<b>Objectives</b>: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided to establish a pharmacokinetic/pharmacodynamic (PK/PD) model of the quinine population in WB using <i>Plasmodiu...