Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation.

• Asıl Yazarlar: Sabine Kuettel (Yazar), Jason Greenwald (Yazar), Dirk Kostrewa (Yazar), Shaheen Ahmed (Yazar), Leonardo Scapozza (Yazar), Remo Perozzo (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2011-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

BACKGROUND: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis. Unlike mammalian cells, trypanosomes lack de novo purine synthesis and completely rely on salvage from their hosts. One of th...