Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation.

• Main Authors: Sabine Kuettel (Author), Jason Greenwald (Author), Dirk Kostrewa (Author), Shaheen Ahmed (Author), Leonardo Scapozza (Author), Remo Perozzo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis. Unlike mammalian cells, trypanosomes lack de novo purine synthesis and completely rely on salvage from their hosts. One of th...