Activation of the Kinin B1 Receptor by Its Agonist Reduces Melanoma Metastasis by Playing a Dual Effect on Tumor Cells and Host Immune Response

• Main Authors: Andrea Gutierrez Maria (Author), Patrícia Dillemburg-Pilla (Author), Marina de Toledo Durand (Author), Elaine Medeiros Floriano (Author), Adriana Oliveira Manfiolli (Author), Simone Gusmão Ramos (Author), João Bosco Pesquero (Author), Clara Nahmias (Author), Claudio M. Costa-Neto (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metastatic melanoma is an aggressive type of skin cancer leading half of the patients to death within 8-10 months after diagnosis. Kinins are peptides that interact with B1 and B2 receptors playing diverse biological roles. We investigated whether treatment with B1 receptor agonist, des-Arg9-bradyki...