Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis

• Main Authors: Ajai J. Pulianmackal (Author), Kiriaki Kanakousaki (Author), Kerry Flegel (Author), Olga G. Grushko (Author), Ella Gourley (Author), Emily Rozich (Author), Laura A. Buttitta (Author)
• Format: Book
• Published: The Company of Biologists, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nucleoporin 98KD (Nup98) is a promiscuous translocation partner in hematological malignancies. Most disease models of Nup98 translocations involve ectopic expression of the fusion protein under study, leaving the endogenous Nup98 loci unperturbed. Overlooked in these approaches is the loss of one co...