Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis-Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1

• Main Authors: Mohamed A. Morsy (Author), Seham A. Abdel-Gaber (Author), Sahar A. Mokhemer (Author), Mahmoud Kandeel (Author), Wael F. Sedik (Author), Anroop B. Nair (Author), Katharigatta N. Venugopala (Author), Hany Ezzat Khalil (Author), Bandar E. Al-Dhubiab (Author), Mervat Z. Mohamed (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical usefulness of doxorubicin (DOX) is limited by its serious adverse effects, such as cardiotoxicity. Pregnenolone demonstrated both anti-inflammatory and antioxidant activity in animal models. The current study aimed to investigate the cardioprotective potential of pregnenolone against DO...