Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis-Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1

• Autors principals: Mohamed A. Morsy (Autor), Seham A. Abdel-Gaber (Autor), Sahar A. Mokhemer (Autor), Mahmoud Kandeel (Autor), Wael F. Sedik (Autor), Anroop B. Nair (Autor), Katharigatta N. Venugopala (Autor), Hany Ezzat Khalil (Autor), Bandar E. Al-Dhubiab (Autor), Mervat Z. Mohamed (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2023-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

The clinical usefulness of doxorubicin (DOX) is limited by its serious adverse effects, such as cardiotoxicity. Pregnenolone demonstrated both anti-inflammatory and antioxidant activity in animal models. The current study aimed to investigate the cardioprotective potential of pregnenolone against DO...