Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells

• Autores principales: Chenkai Huang (Autor), Dakai Gan (Autor), Fangyun Luo (Autor), Sizhe Wan (Autor), Jiang Chen (Autor), Anjiang Wang (Autor), Bimin Li (Autor), Xuan Zhu (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

BackgroundStudies have shown that both NOX4 and RhoA play essential roles in fibrosis and that they regulate each other. In lung fibrosis, NOX4/ROS is located upstream of the RhoA/ROCK1 signaling pathway, and the two molecules are oppositely located in renal fibrosis. Currently, no reports have indi...