Histone-targeted Polyplexes Avoid Endosomal Escape and Enter the Nucleus During Postmitotic Redistribution of ER Membranes

• 主要な著者: Nikki L Ross (著者), Erik V Munsell (著者), Chandran Sabanayagam (著者), Millicent O Sullivan (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2015-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Nonviral gene delivery is a promising therapeutic approach because of its safety and controllability, yet limited gene transfer efficacy is a common issue. Most nonviral strategies rely upon endosomal escape designs; however, endosomal escape is often uncorrelated with improved gene transfer and mem...