Histone-targeted Polyplexes Avoid Endosomal Escape and Enter the Nucleus During Postmitotic Redistribution of ER Membranes

• Auteurs principaux: Nikki L Ross (Auteur), Erik V Munsell (Auteur), Chandran Sabanayagam (Auteur), Millicent O Sullivan (Auteur)
• Format: Livre
• Publié: Elsevier, 2015-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Nonviral gene delivery is a promising therapeutic approach because of its safety and controllability, yet limited gene transfer efficacy is a common issue. Most nonviral strategies rely upon endosomal escape designs; however, endosomal escape is often uncorrelated with improved gene transfer and mem...