A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

• Main Authors: Diogo Crispim Nascimento Portella (Author), Erik Aranha Rossi (Author), Bruno Diaz Paredes (Author), Tanira Matutino Bastos (Author), Cássio Santana Meira (Author), Carolina Vasques Kymie Nonaka (Author), Daniela Nascimento Silva (Author), Alex Improta-Caria (Author), Diogo Rodrigo Magalhaes Moreira (Author), Ana Cristina Lima Leite (Author), Gevanio Bezerra de Oliveira Filho (Author), José Maria Barbosa Filho (Author), Ricardo Ribeiro dos Santos (Author), Milena Botelho Pereira Soares (Author), Bruno Solano de Freita Souza (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease is caused by Trypanosoma cruzi infection and remains a relevant cause of chronic heart failure in Latin America. The pharmacological arsenal for Chagas disease is limited, and the available anti-T. cruzi drugs are not effective when administered during the chronic phase. Cardiomyocyte...