A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

• Главные авторы: Diogo Crispim Nascimento Portella (Автор), Erik Aranha Rossi (Автор), Bruno Diaz Paredes (Автор), Tanira Matutino Bastos (Автор), Cássio Santana Meira (Автор), Carolina Vasques Kymie Nonaka (Автор), Daniela Nascimento Silva (Автор), Alex Improta-Caria (Автор), Diogo Rodrigo Magalhaes Moreira (Автор), Ana Cristina Lima Leite (Автор), Gevanio Bezerra de Oliveira Filho (Автор), José Maria Barbosa Filho (Автор), Ricardo Ribeiro dos Santos (Автор), Milena Botelho Pereira Soares (Автор), Bruno Solano de Freita Souza (Автор)
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• Опубликовано: Hindawi Limited, 2021-01-01T00:00:00Z.
• Предметы: article
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Chagas disease is caused by Trypanosoma cruzi infection and remains a relevant cause of chronic heart failure in Latin America. The pharmacological arsenal for Chagas disease is limited, and the available anti-T. cruzi drugs are not effective when administered during the chronic phase. Cardiomyocyte...