N-isopropyl-(4-methoxy-3-difluoromethyl)cinnamoyl amide targets mycobacterial MmpL3

• Main Authors: Mario D. Martínez (Author), Liliana Rondón (Author), Lisandro Ronconi (Author), Mariano Prado Acosta (Author), Agostina Crotta Asis (Author), Gabriela Gago (Author), Florencia Di Salvo (Author), Gerardo Burton (Author), Fernando Durán (Author), Mariana Piuri (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycobacterial infections still need new and more efficient drugs. In the present work we developed a new and simpler protocol for the synthesis of N-isopropyl-(4-methoxy-3-difluoromethyl)cinnamoyl amide, here named as 3M99F1, a promising candidate for mycobacterial growth inhibition. Using whole gen...