Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice

• Main Authors: Patrick J. Knerr (Author), Stephanie A. Mowery (Author), Jonathan D. Douros (Author), Bhavesh Premdjee (Author), Karina Rahr Hjøllund (Author), Yantao He (Author), Ann Maria Kruse Hansen (Author), Anette K. Olsen (Author), Diego Perez-Tilve (Author), Richard D. DiMarchi (Author), Brian Finan (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Pharmacological strategies that engage multiple mechanisms-of-action have demonstrated synergistic benefits for metabolic disease in preclinical models. One approach, concurrent activation of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and glucagon...