The SAR analysis of dietary polyphenols and their antagonistic effects on bortezomib at physiological concentrations

• Main Authors: Tran Tran Thi Van (Author), Hsun-Shuo Chang (Author), Ho-Cheng Wu (Author), Chung-Kuang Lu (Author), Hui-Chi Huang (Author), Michal Korinek (Author), Hui-Hua Hsiao (Author), Chia-Hung Yen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Bortezomib (BTZ), a primary treatment for MM, but its effectiveness can be reduced by interactions with vicinal diol moieties (VDMs) in polyphenols. Despite this, it's debated whether BTZ therapy necessitates avoiding polyphenol-rich products, given the low bioavailability of polyph...