Deletion of Glyoxalase 1 Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice

• Main Authors: Prakashkumar Dobariya (Author), Wei Xie (Author), Swetha Pavani Rao (Author), Jiashu Xie (Author), Davis M. Seelig (Author), Robert Vince (Author), Michael K. Lee (Author), Swati S. More (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events, culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC), has a narrow therapeutic window, and early treatment is essential for a satisfactory therapeutic outcome. For more versa...