Decrease in Brain Distribution of Fluvoxamine in Experimental Hyperlipidemic Rats

• Main Authors: Keizo Fukushima (Author), Shinji Kobuchi (Author), Masakazu Shibata (Author), Kanji Takada (Author), Nobuyuki Sugioka (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT: Purpose. Many clinical reports and trials have suggested that fluvoxamine (FLV) reduces plasma lipoprotein levels. However, few studies have reported the effect of plasma lipoproteins on FLV pharmacokinetics. The aim of the present study was to investigate the affinities of FLV to plasma l...