Contextualizing single‐arm trials with real‐world data: An emulated target trial comparing therapies for neovascular age‐related macular degeneration

Abstract One‐in‐four ophthalmology trials are single‐armed, which poses challenges to their interpretation. We demonstrate how real‐world cohorts used as external/synthetic control arms can contextualize such trials. We herein emulated a target trial on the intention‐to‐treat efficacy of off‐label b...

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Main Authors: Darren S. Thomas (Author), Aaron Y. Lee (Author), Philipp L. Müller (Author), Roy Schwartz (Author), Abraham Olvera‐Barrios (Author), Alasdair N. Warwick (Author), Praven J. Patel (Author), Tjebo F.C. Heeren (Author), Catherine Egan (Author), Paul Taylor (Author), Adnan Tufail (Author), UK AMD EMR Users Group (Author)
Formato: Livro
Publicado em: Wiley, 2021-05-01T00:00:00Z.
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