Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity

• Main Authors: Mikhail Krasavin (Author), Tatiana Sharonova (Author), Vladimir Sharoyko (Author), Daniil Zhukovsky (Author), Stanislav Kalinin (Author), Raivis Žalubovskis (Author), Tatiana Tennikova (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A hypothesis that simultaneous targeting cancer-related carbonic anhydrase hCA IX and hCA XII isoforms (whose overexpression is a cancer cell's defence mechanism against hypoxia) along with thioredoxin reductase (overexpressed in cancers as a defence against oxidative stress) may lead to synerg...