Exploring the natural products chemical space to abrogate the F3L-dsRNA interface of monkeypox virus to enhance the immune responses using molecular screening and free energy calculations

• Main Authors: Muhammad Suleman (Author), Tanveer Ahmad (Author), Khadim shah (Author), Norah A. Albekairi (Author), Abdulrahman Alshammari (Author), Abbas Khan (Author), Dong-Qing Wei (Author), Hadi M. Yassine (Author), Sergio Crovella (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amid the ongoing monkeypox outbreak, there is an urgent need for the rapid development of effective therapeutic interventions capable of countering the immune evasion mechanisms employed by the monkeypox virus (MPXV). The evasion strategy involves the binding of the F3L protein to dsRNA, resulting i...