Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells

• Main Authors: Jie Zhou (Author), Cheng Peng (Author), Qiuju Li (Author), Xiaoyu Yan (Author), Liang Yang (Author), Mengting Li (Author), Xiaoyu Cao (Author), Xiaofang Xie (Author), Dayi Chen (Author), Chaolong Rao (Author), Sizhou Huang (Author), Fu Peng (Author), Xiaoqi Pan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aconitine is one of the main bioactive and toxic ingredients of Aconitum species. Increasingly, aconitine has been reported to induce neurotoxicity. However, whether aconitine has effects on the dopaminergic nervous system remains unclear. In this study, zebrafish embryos at 6-days postfertilization...