Activation of Proteinase 3 Contributes to Nonalcoholic Fatty Liver Disease and Insulin Resistance

• Main Authors: Erik J M Toonen (Author), Andreea-Manuela Mirea (Author), Cees J Tack (Author), Rinke Stienstra (Author), Dov B Ballak (Author), Janna A van Diepen (Author), Anneke Hijmans (Author), Triantafyllos Chavakis (Author), Wim H Dokter (Author), Christine T N Pham (Author), Mihai G Netea (Author), Charles A Dinarello (Author), Leo A B Joosten (Author)
• Format: Book
• Published: BMC, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes. In addition to caspase-1, the neutrophil serine proteases proteinase 3, neutrophil elastase and cathepsin G are able to...