Activation of Proteinase 3 Contributes to Nonalcoholic Fatty Liver Disease and Insulin Resistance

• Asıl Yazarlar: Erik J M Toonen (Yazar), Andreea-Manuela Mirea (Yazar), Cees J Tack (Yazar), Rinke Stienstra (Yazar), Dov B Ballak (Yazar), Janna A van Diepen (Yazar), Anneke Hijmans (Yazar), Triantafyllos Chavakis (Yazar), Wim H Dokter (Yazar), Christine T N Pham (Yazar), Mihai G Netea (Yazar), Charles A Dinarello (Yazar), Leo A B Joosten (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: BMC, 2016-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes. In addition to caspase-1, the neutrophil serine proteases proteinase 3, neutrophil elastase and cathepsin G are able to...