Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification

• Main Authors: Katarzyna Malenczyk (Author), Edit Szodorai (Author), Robert Schnell (Author), Gert Lubec (Author), Gábor Szabó (Author), Tomas Hökfelt (Author), Tibor Harkany (Author)
• Format: Book
• Published: Elsevier, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Specification of endocrine cell lineages in the developing pancreas relies on extrinsic signals from non-pancreatic tissues, which initiate a cell-autonomous sequence of transcription factor activation and repression switches. The steps in this pathway share reliance on activity-dependent...