Construction of Recombinant Human GM-CSF and GM-CSF-ApoA-I Fusion Protein and Evaluation of Their Biological Activity

• Main Authors: Mariya Pykhtina (Author), Svetlana Miroshnichenko (Author), Vladimir Romanov (Author), Antonina Grazhdantseva (Author), Galina Kochneva (Author), Anatoly Beklemishev (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, two strains of the yeast <i>P. pastoris</i> were constructed, one of which produced authentic recombinant human granulocyte-macrophage colony-stimulating factor (ryGM-CSF), and the other was a chimera consisting of ryGM-CSF genetically fused with mature human apolipoprotei...