Pharmacokinetic and Pharmacogenetic Factors Contributing to Platelet Function Recovery After Single Dose of Ticagrelor in Healthy Subjects

• Main Authors: Qian Zhu (Author), Wanping Zhong (Author), Xipei Wang (Author), Liping Mai (Author), Guodong He (Author), Jiyan Chen (Author), Lan Tang (Author), Shuwen Liu (Author), Weihua Lai (Author), Shilong Zhong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: This study aimed to elucidate the contribution of candidate single nucleotide polymorphisms (SNPs) related to pharmacokinetics on the recovery of platelet function after single dose of ticagrelor was orally administered to healthy Chinese subjects.Methods: The pharmacokinetic profiles of...