Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3

• Main Authors: Song Wu (Author), Yuling Qiu (Author), Yingying Shao (Author), Shuangshuang Yin (Author), Rui Wang (Author), Xu Pang (Author), Junhong Ma (Author), Chunze Zhang (Author), Bo Wu (Author), Sangho Koo (Author), Lifeng Han (Author), Yi Zhang (Author), Xiumei Gao (Author), Tao Wang (Author), Haiyang Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Signal transducer and activator of transcription 3 (STAT3) is an attractive therapeutic target for cancer treatment. In this study, we identify lycorine is an effective inhibitor of STAT3, leading to repression of multiple oncogenic processes in colon carcinoma. Lycorine selectively inactivates phos...