Protocol for a Case-Control Study to Investigate the Association of Pellagra With Isoniazid Exposure During Tuberculosis Preventive Treatment Scale-Up in Malawi

• Main Authors: Scott A. Nabity (Author), Kelvin Mponda (Author), Steve Gutreuter (Author), Diya Surie (Author), Anne Williams (Author), Andrea J. Sharma (Author), Elizabeth R. Schnaubelt (Author), Rebekah E. Marshall (Author), Hannah L. Kirking (Author), Suzgo B. Zimba (Author), Joram L. Sunguti (Author), Laphiod Chisuwo (Author), Mabvuto J. Chiwaula (Author), Jesse F. Gregory (Author), Robin da Silva (Author), Michael Odo (Author), Andreas Jahn (Author), Thokozani Kalua (Author), Rose Nyirenda (Author), Belaineh Girma (Author), James Mpunga (Author), Nicole Buono (Author), Alice Maida (Author), Evelyn J. Kim (Author), Laurence J. Gunde (Author), Tigest F. Mekonnen (Author), Andrew F. Auld (Author), Adamson S. Muula (Author), John E. Oeltmann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Pellagra is caused by niacin (vitamin B3) deficiency and manifested by a distinctive dermatitis. Isoniazid is critical for treating tuberculosis globally and is a component of most regimens to prevent tuberculosis. Isoniazid may contribute to pellagra by disrupting intracellular niacin s...