Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis

• Main Authors: Virginie Carrière (Author), Muhammad Imran Arshad (Author), Jacques Le Seyec (Author), Benjamin Lefevre (Author), Muhammad Farooq (Author), Aurélien Jan (Author), Christelle Manuel (Author), Laurence Touami-Bernard (Author), Catherine Lucas-Clerc (Author), Valentine Genet (Author), Hugues Gascan (Author), Jean-Philippe Girard (Author), Frédéric Chalmel (Author), Lucie Lamontagne (Author), Claire Piquet-Pellorce (Author), Michel Samson (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The alarmin IL-33 has been described to be upregulated in human and murine viral hepatitis. However, the role of endogenous IL-33 in viral hepatitis remains obscure. We aimed to decipher its function by infecting IL-33-deficient mice (IL-33 KO) and their wild-type (WT) littermates with pathogenic mo...