Differential regulation of TNF-α and IL-1β production from endotoxin stimulated human monocytes by phosphodiesterase inhibitors

• Main Authors: K. L. Molnar-Kimber (Author), L. Yonno (Author), R. J. Heaslip (Author), B. M. Weichman (Author)
• 格式: 圖書
• 出版: Hindawi Limited, 1992-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The effect of selective PDE-I (vinpocetine), PDE-III (milrinone, CI-930), PDE-IV (rolipram, nitroquazone), and PDE-V (zaprinast) isozyme inhibitors on TNF-α and IL-1β production from LPS stimulated human monocytes was investigated. The PDE-IV inhibitors caused a concentration dependent inhibition of...