5' Unlocked Nucleic Acid Modification Improves siRNA Targeting

• Main Authors: Nicholas M Snead (Author), Julie R Escamilla-Powers (Author), John J Rossi (Author), Anton P McCaffrey (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Optimization of small interfering RNAs (siRNAs) is important in RNA interference (RNAi)-based therapeutic development. Some specific chemical modifications can control which siRNA strand is selected by the RNA-induced silencing complex (RISC) for gene silencing. Intended strand selection will increa...