Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis

• Main Authors: Di-Zheng Wu (Author), Guo-Zheng Zhu (Author), Kai Zhao (Author), Jia-Wen Gao (Author), Gui-Xing Cai (Author), Hong-Zhou Li (Author), Yu-Sheng Huang (Author), Chen Tu (Author), Jing-Shen Zhuang (Author), Zhi-Wei Huang (Author), Zhao-Ming Zhong (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Increased oxidative stress contributes to enhanced osteoclastogenesis and age-related bone loss. Melatonin (MT) is an endogenous antioxidant and declines with aging. However, it was unclear whether the decline of MT was involved in the enhanced osteoclastogenesis during the aging...