A single mutation (V64G) within the RING Domain of Z attenuates Junin virus.

• Main Authors: Steven J Hallam (Author), John T Manning (Author), Junki Maruyama (Author), Alexey Seregin (Author), Cheng Huang (Author), David H Walker (Author), Juan Carlos de la Torre (Author), Slobodan Paessler (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Junin virus (JUNV) is a New World arenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). Candid#1 (Can) is a live-attenuated vaccine strain of JUNV that since its introduction has resulted in a marked decrease in AHF incidence within the endemic regions of the Pampas in Argenti...