Cationic Dendrimer G2-S16 Inhibits Herpes Simplex Type 2 Infection and Protects Mice Vaginal Microbiome

• Main Authors: Carlos Guerrero-Beltrán (Author), Inmaculada Garcia-Heredia (Author), Rafael Ceña-Diez (Author), Ignacio Rodriguez-Izquierdo (Author), María Jesús Serramía (Author), Francisco Martinez-Hernandez (Author), Mónica Lluesma-Gomez (Author), Manuel Martinez-Garcia (Author), María Ángeles Muñoz-Fernández (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The G2-S16 polyanionic carbosilane dendrimer is a promising microbicide that inhibits HSV-2 infection in vitro and in vivo in mice models. This G2-S16 dendrimer inhibits HSV-2 infection even in the presence of semen. Murine models, such as BALB/c female mice, are generally used to characterize host-...