Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice

• Main Authors: Rebekka Fendt (Author), Ahmed Ghallab (Author), Maiju Myllys (Author), Ute Hofmann (Author), Reham Hassan (Author), Zaynab Hobloss (Author), Daniela González (Author), Lisa Brackhagen (Author), Rosemarie Marchan (Author), Karolina Edlund (Author), Abdel-Latif Seddek (Author), Noha Abdelmageed (Author), Lars M. Blank (Author), Jan-Frederik Schlender (Author), Christian H. Holland (Author), Jan G. Hengstler (Author), Lars Kuepfer (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rationale: Liver cirrhosis is known to affect drug pharmacokinetics, but the functional assessment of the underlying pathophysiological alterations in drug metabolism is difficult.Methods: Cirrhosis in mice was induced by repeated treatment with carbon tetrachloride for 12 months. A cocktail of six...