Aging‐associated skeletal muscle defects in HER2/Neu transgenic mammary tumour model

• Main Authors: Ruizhong Wang (Author), Brijesh Kumar (Author), Poornima Bhat‐Nakshatri (Author), Mayuri S. Prasad (Author), Max H. Jacobsen (Author), Gabriela Ovalle (Author), Calli Maguire (Author), George Sandusky (Author), Trupti Trivedi (Author), Khalid S. Mohammad (Author), Theresa Guise (Author), Narsimha R. Penthala (Author), Peter A. Crooks (Author), Jianguo Liu (Author), Teresa Zimmers (Author), Harikrishna Nakshatri (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Loss of skeletal muscle volume and functional limitations are poor prognostic markers in breast cancer patients. Several molecular defects in skeletal muscle including reduced myoblast determination protein 1 (MyoD) levels and increased protein turn over due to enhanced proteosom...