Discovery of novel arylamide derivatives containing piperazine moiety as inhibitors of tubulin polymerisation with potent liver cancer inhibitory activity

• Main Authors: Xiao-Yi Shi (Author), Huang Jiao (Author), Jia-Kai Zhang (Author), Xin-Yi Tian (Author), Dan-Feng Guo (Author), Jie Gao (Author), Mei-Qi Jia (Author), Jian Song (Author), Sai-Yang Zhang (Author), Xiang-Jing Fu (Author), Hong-Wei Tang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work, a series of novel arylamide derivatives containing piperazine moiety were designed and synthesised as tubulin polymerisation inhibitors. Among 25 target compounds, compound 16f (MY-1121) exhibited low nanomolar IC50 values ranging from 0.089 to 0.238 μM against nine human cancer cells....