Compritol-Based Nanostrucutured Lipid Carriers (NLCs) for Augmentation of Zolmitriptan Bioavailability via the Transdermal Route: In Vitro Optimization, Ex Vivo Permeation, In Vivo Pharmacokinetic Study

• Главные авторы: Doaa H. Hassan (Автор), Joseph N. Shohdy (Автор), Doaa Ahmed El-Setouhy (Автор), Mohamed El-Nabarawi (Автор), Marianne J. Naguib (Автор)
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• Опубликовано: MDPI AG, 2022-07-01T00:00:00Z.
• Предметы: article
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Migraine is a severe neurovascular disease manifested mainly as unilateral throbbing headaches. Triptans are agonists for serotonin receptors. Zolmitriptan (ZMP) is a biopharmaceutics classification system (BCS) class III medication with an absolute oral bioavailability of less than 40%. As a result...