Investigation of Sonication Parameters for Large-Volume Focused Ultrasound-Mediated Blood-Brain Barrier Permeability Enhancement Using a Clinical-Prototype Hemispherical Phased Array

• Main Authors: Dallan McMahon (Author), Ryan M. Jones (Author), Rohan Ramdoyal (Author), Joey Ying Xuan Zhuang (Author), Dallas Leavitt (Author), Kullervo Hynynen (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background/Objectives:</b> Focused ultrasound (FUS) and microbubble (MB) exposure is a promising technique for targeted drug delivery to the brain; however, refinement of protocols suitable for large-volume treatments in a clinical setting remains underexplored. <b>Methods:</...