Rifaximin improves Clostridium difficile toxin A-induced toxicity in Caco-2 cells by the PXR-dependent TLR4/MyD88/NF-κB pathway

• Main Authors: Giuseppe eEsposito (Author), Nicola eNobile (Author), Stefano eGigli (Author), Luisa eSeguella (Author), Marcella ePesce (Author), Alessandra eD'Alessandro (Author), Eugenia eBruzzese (Author), Elena eCapoccia (Author), Luca eSteardo (Author), Rosario eCuomo (Author), Giovanni eSarnelli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Clostridium difficile infections (CDIs) caused by Clostridium difficile toxin A (TcdA) lead to severe ulceration, inflammation and bleeding of the colon, and are difficult to treat.Aim: The study aimed to evaluate the effect of rifaximin on TcdA-induced apoptosis in intestinal epithelial...