Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes

• Main Authors: Jian Huang (Author), Ting Zhang (Author), Julia Kalashova (Author), Jinhua Li (Author), Chenglu Yang (Author), Linsheng Zhong (Author), Xiaohu Zhou (Author), Qiong Shi (Author), Gang Lv (Author), Jiadai Chenyu (Author), Yidan Xia Abuliezi (Author), Duo Yu (Author), Xuejiao Jiang (Author), Mallu Chenna Reddy (Author), Namrta Choudhry (Author), Naganna Nimishetti (Author), Dun Yang (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitotic kinesin-like protein 2 (MKLP2/KIF20A) is a key mitotic regulator frequently overexpressed in human malignancies and its abundance is positively correlated with poor outcomes of the disease. Despite extensive research on MKLP2 as a potential target for oncology, the development of small-molec...