CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate

• প্রধান লেখক: Laura Danti (লেখক), Karolina Lundin (লেখক), Kirsi Sepponen (লেখক), Dawit A. Yohannes (লেখক), Juha Kere (লেখক), Timo Tuuri (লেখক), Juha S. Tapanainen (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: BMC, 2023-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract The nuclear receptor subfamily 5 group A member 1 (NR5A1), encoding steroidogenic factor 1 (SF-1), has been identified as a critical factor in gonadal development in animal studies. A previous study of ours suggested that upregulation of NR5A1 during early gonadal differentiation in male (4...