IMPACT OF ABCB1 AND CES1 GENETIC POLYMORPHISMS ON TROUGH STEADY-STATE DABIGATRAN CONCENTRATIONS IN PATIENTS AFTER ENDOPROSTHESIS OF KNIFE JOIN

• Main Authors: D. A. Sychev (Author), A. N. Levanov (Author), T. V. Shelekhova (Author), P. O. Bochkov (Author), N. Р. Denisenko (Author), K. A. Ryzhikova (Author), K. В. Mirzaev (Author), E. A. Grishina (Author), M. A. Gavrilov (Author)
• Format: Bog
• Udgivet: «REMEDIUM GROUP» Ltd., 2018-05-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Oral anticoagulants are widely used to prevent thromboembolic events in patients following total knee arthroplasty [1]. The genetic characteristics of patients affect the efficacy and safety of anticoagulants [2]. Dabigatran etexilate is a direct inhibitor of thrombin used as a prophylaxis of venous...