QT PRODACT: A Multi-site Study of In Vitro Action Potential Assays on 21 Compounds in Isolated Guinea-Pig Papillary Muscles

• Main Authors: Seiji Hayashi (Author), Yoshihide Kii (Author), Mitsuyasu Tabo (Author), Hitoshi Fukuda (Author), Tetsuji Itoh (Author), Takashi Shimosato (Author), Hideto Amano (Author), Mamoru Saito (Author), Hajime Morimoto (Author), Kiyoshi Yamada (Author), Atsuhiro Kanda (Author), Toshimasa Ishitsuka (Author), Takanobu Yamazaki (Author), Yoichi Kiuchi (Author), Shinya Taniguchi (Author), Tatsuya Mori (Author), Shigekazu Shimizu (Author), Yuji Tsurubuchi (Author), Shun-ichi Yasuda (Author), Shin-ichi Kitani (Author), Chiaki Shimada (Author), Kazuo Kobayashi (Author), Masaharu Komeno (Author), Chieko Kasai (Author), Toshiyasu Hombo (Author), Keiji Yamamoto (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To construct a non-clinical database for drug-induced QT interval prolongation, the electrophysiological effects of 11 positive and 10 negative compounds on action potentials (AP) in guinea-pig papillary muscles were investigated in a multi-site study according to a standard protocol. Compounds with...