Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells

• Main Authors: Tadaatsu Imaizumi (Author), Chikashi Yano (Author), Akiko Numata (Author), Koji Tsugawa (Author), Ryo Hayakari (Author), Tomoh Matsumiya (Author), Hidemi Yoshida (Author), Shojiro Watanabe (Author), Kazushi Tsuruga (Author), Shogo Kawaguchi (Author), Manabu Murakami (Author), Hiroshi Tanaka (Author)
• Format: Book
• Published: Karger Publishers, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Activation of Toll-like receptor 3 (TLR3) signaling followed by type I interferon (IFN) expression is crucial in antiviral and "pseudoviral" immune reactions in renal mesangial cells (MCs). These reactions are probably involved in the pathogenesis of chronic kidney disease...