Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles

• Main Authors: Amrita Kadari (Author), Sagarika Gudem (Author), Hitesh Kulhari (Author), Murali Mohan Bhandi (Author), Roshan M. Borkar (Author), Venkata Ramana Murthy Kolapalli (Author), Ramakrishna Sistla (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fisetin (FST), a potent anticancer phytoconstituent, exhibits poor aqueous solubility and hence poor bioavailability. The aim of the present study is to improve the oral bioavailability of FST by encapsulating into PLGA NPs (poly-lactide-co-glycolic acid nanoparticles) as a complex of HPβCD (hydroxy...