Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways

• Автори: Jiyong Wei (Автор), Yicheng Li (Автор), Qian Liu (Автор), Yanni Lan (Автор), Chengming Wei (Автор), Kun Tian (Автор), Liwei Wu (Автор), Chunbo Lin (Автор), Jiake Xu (Автор), Jinmin Zhao (Автор), Yuan Yang (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Osteoclasts with elevated bone resorption are commonly present in postmenopausal osteoporosis, and other osteolytic pathologies. Therefore, suppressing osteoclast generation and function has been the main focus of osteoporosis treatment. Betulinic acid (BA) represents a triterpenoid mainly purified...