Selective and rapid determination of raltegravir in human plasma by liquid chromatographyâtandem mass spectrometry in the negative ionization mode

• Main Authors: Ajay Gupta (Author), Swati Guttikar (Author), Priyanka A. Shah (Author), Gajendra Solanki (Author), Pranav S. Shrivastav (Author), Mallika Sanyal (Author)
• Format: Book
• Published: Elsevier, 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A selective and rapid high-performance liquid chromatographyâtandem mass spectrometry method was developed and validated for the quantification of raltegravir using raltegravir-d3 as an internal standard (IS). The analyte and IS were extracted with methylene chloride and n-hexane solvent mixture fro...