Selective and rapid determination of raltegravir in human plasma by liquid chromatographyâtandem mass spectrometry in the negative ionization mode

• المؤلفون الرئيسيون: Ajay Gupta (مؤلف), Swati Guttikar (مؤلف), Priyanka A. Shah (مؤلف), Gajendra Solanki (مؤلف), Pranav S. Shrivastav (مؤلف), Mallika Sanyal (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2015-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

A selective and rapid high-performance liquid chromatographyâtandem mass spectrometry method was developed and validated for the quantification of raltegravir using raltegravir-d3 as an internal standard (IS). The analyte and IS were extracted with methylene chloride and n-hexane solvent mixture fro...