TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage

• Main Authors: Wenjun Yu (Author), Haixia Xu (Author), Zhe Sun (Author), Yuxin Du (Author), Shiqun Sun (Author), Miyesaier Abudureyimu (Author), Mengjiao Zhang (Author), Jun Tao (Author), Junbo Ge (Author), Jun Ren (Author), Yingmei Zhang (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clinical application of doxorubicin (DOX) is heavily hindered by DOX cardiotoxicity. Several theories were postulated for DOX cardiotoxicity including DNA damage and DNA damage response (DDR), although the mechanism(s) involved remains to be elucidated. This study evaluated the potential role of TBC...