Overexpression of ABCB1 Associated With the Resistance to the KRAS-G12C Specific Inhibitor ARS-1620 in Cancer Cells

• Main Authors: Xing-Duo Dong (Author), Meng Zhang (Author), Chao-Yun Cai (Author), Qiu-Xu Teng (Author), Jing-Quan Wang (Author), Yi-Ge Fu (Author), Qingbin Cui (Author), Ketankumar Patel (Author), Dong-Tao Wang (Author), Zhe-Sheng Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The KRAS-G12C inhibitor ARS-1620, is a novel specific covalent inhibitor of KRAS-G12C, possessing a strong targeting inhibitory effect on KRAS-G12C mutant tumors. Overexpression of ATP-binding cassette super-family B member 1 (ABCB1/P-gp) is one of the pivotal factors contributing to multidrug resis...