Proline‐rich transmembrane protein 2 regulates the magnitude and frequency of dopamine release by repetitive neuronal stimuli in the striatum of L‐dopa‐treated mice

• Main Authors: Daisuke Hatta (Author), Shiho Makiya (Author), Kaito Kanamoto (Author), Kaori Watanabe (Author), Yuki Fuchigami (Author), Shigeru Kawakami (Author), Akira Kinoshita (Author), Koh‐Ichiro Yoshiura (Author), Naohiro Kurotaki (Author), Keiro Shirotani (Author), Nobuhisa Iwata (Author)
• Format: Book
• Published: Wiley, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Mutations in proline‐rich transmembrane protein 2 (PRRT2) cause paroxysmal kinesigenic dyskinesia (PKD). Recently, we reported that a Prrt2 mutation exacerbated L‐dopa‐induced motor deficits in mice, suggesting that the basal ganglia might contribute to PKD pathology. Here, we demonstrated...