Hsa_circ_0043532 contributes to PCOS through upregulation of CYP19A1 by acting as a ceRNA for hsa-miR-1270

• Main Authors: Huimin Zhang (Author), Jianye Fang (Author), Yingxue Liu (Author), Wenqian Zhu (Author), Yangying Xu (Author), Yu Zhang (Author), Wei Shen (Author), Duan Li (Author), Cuifang Hao (Author)
• Format: Book
• Published: BMC, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Polycystic ovarian syndrome (PCOS) accounts for about 75% of anovulatory infertility. The cause of PCOS is not clear. CircRNAs acting as miRNA sponges mediate the post-transcriptional regulation of multiple genes. CYP19A1 is a limiting enzyme in the ovarian steroidogenesis pathwa...